DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Oral erythromycin accelerates impaired gastrointestinal motility after endoscopic mucosal resection.

Author(s): Kawamura O, Kusano M, Shimoyama Y, Horikoshi T, Sekiguchi T, Mori M

Affiliation(s): Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Gunma, Maebashi, Japan. osamuk@med.gunma-u.ac.jp

Publication date & source: 2007-09, Dig Dis Sci., 52(9):2211-20. Epub 2007 Apr 6.

Publication type: Randomized Controlled Trial

Gastrointestinal motility may be impaired after endoscopic mucosal resection of gastric lesions. We investigated whether oral erythromycin could improve motility. Twenty patients were divided randomly into groups that received oral omeprazole with or without erythromycin. Motility was recorded overnight at 3 days before and 4 days after endoscopic resection using a microtransducer probe. In the group without erythromycin, gastric phase III activity decreased significantly after endoscopic resection, while it was increased significantly by erythromycin (P < 0.01). After resection, there were significantly more gastric phase III events in the erythromycin group (P < 0.05). The interval between the start of the evening meal and the initial gastric phase III activity was significantly prolonged after resection, while this interval was significantly shortened by erythromycin (P < 0.05). The gastric phase III cycle length was also significantly shortened by erythromycin (P < 0.05). Postprandial and fasting gastrointestinal motility were impaired after endoscopic resection, and postprandial as well as fasting motility were improved by oral erythromycin.

Page last updated: 2008-08-11

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017