Intravenous immunoglobulins in the treatment of immune neuropathies.

Author(s): Kieseier BC, Meyer Zu Horste G, Lehmann HC, Gold R, Hartung HP

Affiliation(s): Department of Neurology, Heinrich-Heine-University, Duesseldorf, Germany. bernd.kieseier@uni-duesseldorf.de

Publication date & source: 2008-10, Curr Opin Neurol., 21(5):555-62.

Publication type: Review

PURPOSE OF REVIEW: The aim of this review is to describe the value of high-dose polyclonal intravenous immunoglobulins as a treatment option in autoimmune disorders affecting the peripheral nervous system. RECENT FINDINGS: A randomized placebo-controlled trial in patients with chronic inflammatory demyelinating polyradiculoneuropathy revealed short-term and long-term efficacy and safety of intravenous immunoglobulins as a treatment option for the chronically inflamed peripheral nervous system. Case reports suggest that the subcutaneous administration of immunoglobulins may represent a convenient alternative. SUMMARY: Intravenous immunoglobulin represents an effective and safe treatment option in patients with autoimmune-mediated diseases affecting the peripheral nerves.