DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

A randomized trial of the effect of testosterone and estrogen on verbal fluency, verbal memory, and spatial ability in healthy postmenopausal women.

Author(s): Kocoska-Maras L, Zethraeus N, Radestad AF, Ellingsen T, von Schoultz B, Johannesson M, Hirschberg AL

Affiliation(s): Department of Women's and Children's Health, Division of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, Sweden.

Publication date & source: 2010-07-27, Fertil Steril., [Epub ahead of print]

OBJECTIVE: To test the causal relationship between sex hormones and cognitive skills in postmenopausal women. We hypothesized that testosterone would decrease verbal memory and verbal fluency and increase spatial ability compared with a placebo. For estrogen, we conversely hypothesized that the treatment would increase verbal fluency and verbal memory and decrease spatial ability. DESIGN: Randomized, double-blind, placebo-controlled, parallel-group trial. SETTING: Women's health clinical research unit at a university hospital. PATIENT(S): Two-hundred healthy, naturally postmenopausal women aged 50-65 years. INTERVENTION(S): Randomization to 4 weeks' treatment with testosterone (testosterone undecanoate, 40 mg/day), estrogen (oral E(2) 2 mg/day) or placebo. MAIN OUTCOME MEASURE(S): Comparisons in verbal fluency, verbal memory, and spatial ability between the three treatment groups. RESULT(S): We found no significant effects of testosterone or estrogen on verbal fluency, verbal memory, or spatial ability. CONCLUSION(S): Our results give no support for short-term testosterone or estrogen treatment having any substantial effect on verbal fluency, verbal memory, or spatial ability in healthy postmenopausal women. Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Page last updated: 2010-10-05

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017