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Comparison of the effects of nicardipine and sodium nitroprusside for control of increased blood pressure after coronary artery bypass graft surgery.

Author(s): Kwak YL, Oh YJ, Bang SO, Lee JH, Jeong SM, Hong YW

Affiliation(s): Department of Anaesthesiology, Yonsei University College of Medicine, Seoul, Korea.

Publication date & source: 2004-07, J Int Med Res., 32(4):342-50.

Publication type: Clinical Trial; Randomized Controlled Trial

We compared the haemodynamic effects of nicardipine and sodium nitroprusside after coronary artery bypass graft surgery. When post-surgery systolic blood pressure reached > 150 mmHg, patients were randomly given nicardipine (N group, n = 26) or sodium nitroprusside (S group, n = 21). The drugs were infused at a rate of 2 microg/kg per min for 10 min. If the target blood pressure (120-140 mmHg) was not achieved, the infusion rate was increased by 1 microg/kg per min every 10 min. Cardiac and stroke volume indices had increased significantly in the N group after 10 min and in both groups after 60 min. The infusion duration and total dose of drug were significantly lower in the N group compared with the S group. Nicardipine infusion controlled post-operative hypertension more rapidly and was superior to sodium nitroprusside in maintaining left ventricular performance immediately after drug infusion.

Page last updated: 2006-01-31

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