DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Rapid reduction of hard exudates in eyes with diabetic retinopathy after intravitreal triamcinolone: data from a randomized, placebo-controlled, clinical trial.

Author(s): Larsson J, Kifley A, Zhu M, Wang JJ, Mitchell P, Sutter FK, Gillies MC

Affiliation(s): Department of Clinical Ophthalmology, Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia.

Publication date & source: 2008-09-10, Acta Ophthalmol., [Epub ahead of print]

Purpose: To assess the effect of triamcinolone acetonide over 3 months on hard exudates in patients with diabetic macular oedema (DMO). Methods: Thirty-two eyes of 16 patients with DMO and hard exudates were included in a randomized, placebo-controlled trial. Treated eyes received a single-dose (4 mg) intravitreal injection of triamcinolone acetonide. Control eyes received an injection of subconjunctival saline. Results: The overall area of hard exudates decreased significantly between the baseline and 3-month visits in treated eyes, but not in control eyes. The mean change in level of hard exudates between the two visits was - 0.75 arbitrary units (AU) (95% confidence interval [CI] - 1.32 to - 0.18) in the central plus inner circle (1500 mum) and - 0.81 AU (95% CI - 1.49 to - 0.13) over the whole grid (3000 mum) in treated eyes, compared with 0.31 AU (95% CI - 0.19 to 0.82) and 0.31 AU (95% CI - 0.11 to 0.74), respectively, in control eyes (p < 0.001). Mean visual acuity improved by five letters in treated but not in control eyes (p = 0.01). Conclusions: Intravitreal triamcinolone reduces hard exudates in the short-term in eyes with DMO.

Page last updated: 2008-11-03

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017