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Does increasing the steroid dose enhance the efficacy of the antiemetic combination of granisetron and methylprednisolone in gynecologic cancer patients--a randomized study.

Author(s): Lehoczky O, Udvary J, Bagameri A, Pulay T

Affiliation(s): Gynecologic Oncology Department, National Institute of Oncology, Rath Gy.u. 7-9, H-1122 Budapest, Hungary. lehoczky@oncol.hu

Publication date & source: 2004-03-15, Eur J Obstet Gynecol Reprod Biol., 113(1):94-7.

Publication type: Clinical Trial; Randomized Controlled Trial

OBJECTIVE: The authors administered two doses of oral methylprednisolone in combination with 3mg granisetron intravenously for the prophylaxis of cisplatin-induced emesis in gynecologic cancer patients. MATERIALS AND METHODS: Thirty-nine patients received 100mg (group A) and 25 received 200mg (group B) methylprednisolone in the antiemetic combination in a randomized prospective trial. RESULTS: No vomiting in 90.2 and 96.7%, one emetic episode in 3 and 1.1% and two episodes in 3 and 2.2% were detected in groups A and B, respectively. More than two emetic episodes were considered to be a failure and were observed only in group A (3.8%). There was no significant difference between the two treatment groups (P=0.3160). CONCLUSIONS: There was no evidence for enhanced antiemetic effect of elevated steroidal dose in combination with granisetron.

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