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Comparison of intramuscular recombinant alpha interferon (rIFN-2A) with topical acyclovir for the treatment of first-episode herpes genitalis and prevention of recurrences.

Author(s): Levin MJ, Judson FN, Eron L, Bryson YJ, Corey L, Murray M, Scheer RR

Affiliation(s): Pediatric Infectious Diseases Section, University of Colorado School of Medicine, Denver 80262.

Publication date & source: 1989-05, Antimicrob Agents Chemother., 33(5):649-52.

Publication type: Clinical Trial; Controlled Clinical Trial; Randomized Controlled Trial

Intramuscular recombinant alpha interferon (rIFN-2A; 9 million IU given for 5 days during a 9-day treatment period) was compared with topical acyclovir in a double-blind, placebo-controlled trial for the treatment of first-episode genital herpes simplex virus (HSV) infection and for subsequent alteration of the frequency of recurrences. rIFN-2A (within 96 h of onset of the first episode) was not superior to topical acyclovir in a well-matched group of 105 patients. The early use of rIFN-2A also did not alter the frequency or severity of genital HSV recurrences within either the first or second 6 months following therapy. Separate analyses by HSV type and by type of infection (primary versus nonprimary) did not change this conclusion. Furthermore, there was significant toxicity associated with rIFN-2A therapy. rIFN-2A is not indicated for the treatment of genital HSV infections.

Page last updated: 2006-01-31

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