[Treating influenza patients of wind-heat affecting Fei syndrome by jinhua
qinggan granule: a double-blinded randomized control trial]. [Article in Chinese]
Author(s): Li GQ(1), Zhao J(2), Tu ZT(2), Li JB(2), Liu QQ(2), Shi LQ(3), Miao Q(4), Yuan
HQ(5), Liu XQ(6), Long YY(7), Liu ZG(1), Zhao T(1), Li L(1), Tant QH(8), He
YC(9), Bian YJ(1), Hu JQ(1).
Affiliation(s): Author information:
(1)Respiratory Department, Guang'anmen Hospital Affiliated to China Academy of
Chinese Medical Sciences, Beijing 100053, China.
(2)Emergency Department, Dongzhimen Hospital Affiliated to Bejing University of
Chinese Medicine, Beijing 100700, China.
(3)Respiratory Department, Dongfang Hospital Affiliated to Beijing University of
Chinese Medicine, Beijing 100078, China.
(4)Respiratory Department, Xiyuan Hospital Affiliated to China Academy of Chinese
Medical Sciences, Beijing 100091, China.
(5)Respiratory Department, Beijing Chinese Medicine Hospital Affiliated to Capital
Medical University, Beijing 100010, China.
(6)Respiratory Department, First Hospital Affiliated to Tianjin University of Tradi
tional Chinese Medicine, Tianjin 300193, China.
(7)Respiratory Department, Second Hospital Affiliated to Tianjin University of
Traditional Chinese Medicine, Tianjin 300151, China.
(8)Beijing Supertrack Medical Technology Development Co., Ltd., Beijing 100029,
China.
(9)Clinical Medicine Research Center, Shanghai University of Traditional Chinese
Medicine, Shanghai 201203, China.
Publication date & source: 2013, Zhongguo Zhong Xi Yi Jie He Za Zhi. , 33(12):1631-5
OBJECTIVE: To assess the effect and safety of Jinhua Qinggan Granule (JHG) in
treating influenza patients of wind-heat affecting Fei syndrome (WHAFS).
METHODS: Totally 136 influenza patients of WHAFS were randomized by
stratification into 3 groups, the high dose JHG group (44 cases, 10 g each time),
the low dose JHG group (45 cases, 5 g JHG + 5 g placebo each time), and the
placebo control group (47 cases, 10 g placebo each time). All medication was
administered three times daily for 5 days. The fever disappearance time, the
fever disappearance rate, efficacy of TCM syndrome, the disappearance rate of
main symptoms and physical signs of flu, the negative rate of virus nucleic acid
in the pharyngeal secretion, and safety indicators were assessed.
RESULTS: The median fever disappearance time was 32.8 h (95% CI: 22.5-41.0 h) in
the high dose JHG group, 26.0 h (95% CI: 14.5-36.5 h) in the low dose JHG group,
39.5 h (95% CI: 29.0-46.0 h) in the placebo control group. There was statistical
difference in the median fever disappearance time between the low dose JHG group
and the placebo control group (P = 0.011). Three days after treatment, the
markedly effective rate of TCM symptoms in the low dose JHG group was 66.7%,
higher than that of the placebo control group (38.3%), and its effective rate was
superior to that of the high dose JHG group (P = 0.043). Five days after
treatment, the recovery rate of the low dose JHG group (42.2%) was higher than
that of the high dose JHG group (25.0%, P = 0.026) and that of the placebo
control group (14.9%, P = 0.002). The markedly effective rate of the low dose JHG
group (86.7%) was higher than that of the placebo control group (55.3%, P =
0.001). Similar effects were obtained in the low dose JHG group and the high dose
JHG group, but slightly poor in partial indicators of the high dose JHG group.
There was no statistical difference in adverse reaction among these three groups
(P > 0.05).
CONCLUSIONS: JHG was effective and safe in treating influenza patients of WHAFS.
Routinely low dose was the optimal dosage of JHG.
|