[Effects of intranasal cortocosteroidson on the expression of Aquaporin-5 in human nasal polyps]

Author(s): Li Z, Gao Q, Zhen H, Cui Y

Affiliation(s): Department of Otolaryngology, Tongji Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, 430030, China.

Publication date & source: 2004-11, Lin Chuang Er Bi Yan Hou Ke Za Zhi., 18(11):647-9.

Publication type: Randomized Controlled Trial

OBJECTIVE: To observe the effects of intranasal Fluticasone propionate on the expression of Aquaporin-5 in nasal polyps and explore the role of AQP-5 in the formation of nasal polyps. METHOD: Twenty cases of nasal polyps were selected. Fluticasone propionate were intranasally used in 10 cases of nasal polyps for 7-10 days before operation. The others, treated with nothing, were used as control. Twenty samples nasal polyps were obtained and studied with immunochemistric technique. RESULT: The expression of AQP-5 positive cells in the blood vessel endothelium was statistically significantly redueced in the Fluticasone propionate-using group compared with the control group (P < 0.05). The difference of AQP-5 positive cells in mucosal epithelial and glandular epithelium was not statistically significant between the Fluticasone propionate-using group and the control group. CONCLUSION: (1) AQP-5 might be a vital factor for the formation edema of nasal polyps. (2) The effects of Fluticasone propionate on nasal polyps may be related to changing the expression of AQP-5 to a degree. (3) The full exploration of regulation and control of Aquaporions can contribute to evaluate the pathogenesis of nasal polyps.