Effectiveness of vaginal administration of Lactobacillus rhamnosus following conventional metronidazole therapy: how to lower the rate of bacterial vaginosis recurrences.
Author(s): Marcone V, Calzolari E, Bertini M
Affiliation(s): Department of Gynaecology, Perinatology and Child Health-Gynaecologic Infections and Cervicovaginal Pathology Unit, University "La Sapienza", Rome, Italy. valentinamarcone@libero.it
Publication date & source: 2008-07, New Microbiol., 31(3):429-33.
Eighty-four patients with bacterial vaginosis diagnosed according to Amsel's criteria were randomized to receive either oral metronidazole 500 mg twice a day for seven days, or one vaginal tablet containing freeze-dried Lactobacillus rhamnosus once a week at bedtime for two months starting one week after the last antibiotic administration. Followup was performed at days 30, 90 and 180. Chi-squared analysis showed a significant difference between the two treatment groups at day 90 (P = 0.05). Safe and effective long-term vaginal administration of Lactobacillus rhamnosus appears to be a useful complementary approach in the management of bacterial vaginosis.
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