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In vitro activity of chloramphenicol alone and in combination with vancomycin, ampicillin, or RP 59500 (quinupristin/dalfopristin) against vancomycin-resistant enterococci.

Author(s): Messick CR, Pendland SL

Affiliation(s): Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago 60612, USA.

Publication date & source: 1997-11, Diagn Microbiol Infect Dis., 29(3):203-5.

Using a checkerboard assay, ampicillin, vancomycin, and RP 59500, each in combination with chloramphenicol, were tested for synergy against 23 isolates of vancomycin-resistant enterococci. Additive effects were seen in 62.5% of the isolates when exposed to chloramphenicol plus RP 59500. Additive effects were observed in 20% and 15% of isolates with chloramphenicol plus vancomycin or ampicillin, respectively. No antagonism was noted.

Page last updated: 2006-01-31

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