Potency ranking of two new topical corticosteroid creams containing 0.1% desonide or 0.05% halometasone utilising the human skin blanching assay.

Author(s): Meyer E, Smith EW, Haigh JM, Kanfer I

Affiliation(s): School of Pharmaceutical Sciences, Rhodes University, Grahamstown, South Africa.

Publication date & source: 1988-12, Arzneimittelforschung., 38(12):1840-3.

Publication type: Clinical Trial; Randomized Controlled Trial

The human blanching assay was used to assess the potency of two new proprietary corticosteroid creams. The blanching abilities of 0.1% desonide cream and 0.05% halometasone cream were evaluated relative to the blanching elicited by 0.05% clobetasol 17-propionate cream, 0.1% betamethasone 17-valerate cream and 0.05% clobetasone 17-butyrate cream. The results of the trial indicated that the 0.1% desonide cream falls into the potent group of topical corticosteroid preparations and the 0.05% halometasone cream falls into the moderately potent group.