Oral resveratrol and calcium fructoborate supplementation in subjects with stable
angina pectoris: effects on lipid profiles, inflammation markers, and quality of
life.
Author(s): Militaru C(1), Donoiu I, Craciun A, Scorei ID, Bulearca AM, Scorei RI.
Affiliation(s): Author information:
(1)Craiova Cardiology Center, Craiova, Romania.
Publication date & source: 2013, Nutrition. , 29(1):178-83
OBJECTIVE: This study aimed to evaluate the effects of short-term (60-d) oral
supplementation with calcium fructoborate, resveratrol, and their combination on
the clinical and biological statuses of subjects with stable angina pectoris.
METHODS: A randomized, double-blinded, active-controlled, parallel clinical trial
was conducted in three groups of subjects. Of the total number of subjects
included in study (n = 166), 87 completed the 60-d test treatment study period
and 29 followed in parallel their usual medical care and treatment. The primary
outcomes were inflammation biomarkers (high-sensitivity C-reactive protein), left
ventricular function markers (N-terminal prohormone of brain natriuretic
peptide), and lipid markers (total cholesterol, low-density lipoprotein
cholesterol, high-density lipoprotein cholesterol, and triacylglycerols). Quality
of life was assessed by the Canadian Cardiovascular Society angina class and the
number of angina attacks per week.
RESULTS: There was a significant decrease of high-sensitivity C-reactive protein
in all groups at the 30-d and 60-d visits. This decrease was greater (39.7% at 60
d) for group 3 (calcium fructoborate), followed by group 2 (resveratrol plus
calcium fructoborate, 30.3% at 60 d). The N-terminal prohormone of brain
natriuretic peptide was significantly lowered by resveratrol (group 1, 59.7% at
60 d) and by calcium fructoborate (group 3, 52.6% at 60 d). However, their
combination (group 2) was the most effective and induced a decrease of 65.5%.
Lipid markers showed slight changes from baseline in all groups. The improvement
in the quality of life was best observed for subjects who received the
resveratrol and calcium fructoborate mixture (group 2).
CONCLUSION: The results indicate that the combination of resveratrol and calcium
fructoborate has beneficial effects in patients with angina
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