Omeprazole-Mg 20.6 mg is superior to lansoprazole 15 mg for control of gastric
acid: a comparison of over-the-counter doses of proton pump inhibitors.
Author(s): Miner PB Jr, McKean LA, Gibb RD, Erasala GN, Ramsey DL, McRorie JW.
Affiliation(s): Oklahoma Foundation for Digestive Research, Oklahoma City, OK, USA.
Publication date & source: 2010, Aliment Pharmacol Ther. , 31(8):846-51
BACKGROUND: Over-the-counter (OTC) proton pump inhibitors (PPIs) relieve
heartburn by decreasing the production of gastric acid, but may not do so with
equal effectiveness. It is important for healthcare professionals to compare the
ability of OTC PPIs to control gastric acid when recommending them for patients
with frequent heartburn.
AIM: To compare the effects of omeprazole-Mg 20.6 mg and lansoprazole 15 mg (OTC
doses in the US) on 24-h steady state gastric acid suppression.
METHODS: This single-centre, randomized, double-blind clinical study compared the
steady-state gastric acid control of omeprazole-Mg 20.6 mg vs. lansoprazole 15
mg, dosed before breakfast. Volunteers were enrolled in a 3-period, cross-over
design (ABB, BAA) with 24-h gastric pH monitoring on dosing day 5. The primary
efficacy variable was the percentage time intragastric pH was >4.0 over 24 h on
day 5 of dosing.
RESULTS: Forty subjects were enrolled; all completed the study. The mean (SE)
percentage time pH was >4.0 was 45.7% (3.45%) for omeprazole-Mg 20.6 mg and 36.8%
(3.45%) for lansoprazole 15 mg, an absolute difference of 8.9% (P < 0.0001), and
a relative difference of 24.2%. Both drugs were well tolerated.
CONCLUSION: Omeprazole-Mg 20.6 mg provided a statistically significantly (P <
0.0001) greater acid control than lansoprazole 15 mg.
|