Double-blind, crossover comparison of olopatadine and cetirizine versus placebo: suppressive effects on skin response to histamine iontophoresis.
Author(s): Morita E, Matsuo H, Zhang Y
Affiliation(s): Department of Dermatology, School of Medicine, Shimane University, Enya-cho 89-1, Izumo 693-8501, Japan.
Publication date & source: 2005-01, J Dermatol., 32(1):58-61.
Publication type: Clinical Trial; Randomized Controlled Trial
Olopathadine, a newly developed histamine H1-receptor antagonist, was compared with cetirizine in its suppressive effects on histamine-induced wheal and flare reaction using an iontophoresis technique in a double-blind, crossover, placebo-controlled fashion. As a result, olopathadine was found to have effects comparable to cetirizine. This finding may predict the efficacy of this new H1-antagonist in treating pruritic skin diseases.
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