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Double-blind, crossover, placebo-controlled clinical trial with clobetasol propionate in desquamative gingivitis.

Author(s): Motta AC, Domaneschi C, Komesu MC, Souza Cda S, Aoki V, Migliari DA

Affiliation(s): Department of Oral Diagnosis, University of Sao Paulo, SP, Brazil.

Publication date & source: 2009, Braz Dent J., 20(3):231-6.

Publication type: Research Support, Non-U.S. Gov't

The aim of this study was to evaluate the efficacy of a 0.05% clobetasol propionate ointment administered in trays to 22 patients with desquamative gingivitis in a double-blind, crossover, placebo-controlled trial. Patients received container number 1 and were instructed to apply the ointment 3 times a day for 2 weeks, and to reduce the application to once a day in the third week. Next, the patients were then instructed to discontinue the treatment for 2 weeks, and were then given container 2, used in the same way and for the same length of time as container 1. Regarding signs, 17 patients presented some improvement, while 5 experienced worsening with clobetasol propionate. With the placebo, 14 patients presented some improvement, and 8 patients presented worsening. For symptoms, there was complete improvement in 2 patients, partial improvement in 12, no response in 7, and worsening in 1 with clobetasol propionate. With the placebo, there was partial improvement in 8 patients, no response in 12 and worsening in 2. No statistically significant difference was found between clobetasol and placebo (p>0.05). Within the period designed to treat the gingival lesions of the patients, clobetasol propionate did not significantly outperform the placebo.

Page last updated: 2009-10-20

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