Life-threatening infection with multiresistant Staphylococcus epidermidis in a patient with end-stage renal disease: cure with chloramphenicol and quinupristin/dalfopristin (RP 59500).

Author(s): Mundlein E, von Baum H, Geiss HK, Springsklee M, Zeier M, Andrassy K

Affiliation(s): Medizinische Universitatsklinik, Heidelberg, Germany.

Publication date & source: 1997-07, Infection., 25(4):252-4.

Publication type: Case Reports

A 45-year-old man with end-stage renal disease underwent a cadaveric kidney transplantation. The allograft had to he removed 10 days after transplantation because of an acute vascular rejection. After explantation, the patient suffered from a life-threatening infection with Staphylococcus epidermidis involving lungs, eyes and liver for 11 months. Despite adequate therapy including vancomycin followed by teicoplanin, he developed spondylodiscitis requiring repeated surgical interventions. The definitive cure was achieved by a sequential therapy with chloramphenicol and quinupristin/dalfopristin.