Postprandial glucose-lowering effects of fermented red ginseng in subjects with
impaired fasting glucose or type 2 diabetes: a randomized, double-blind,
placebo-controlled clinical trial.
Author(s): Oh MR, Park SH, Kim SY, Back HI, Kim MG, Jeon JY, Ha KC, Na WT, Cha YS, Park BH,
Park TS(1), Chae SW.
Affiliation(s): Author information:
(1)Clinical Trial Center for Functional Food, Chonbuk National University Hospital,
20 Geonji-ro, Jeonju, Jeonbuk 561-712, Republic of Korea. pts@jbnu.ac.kr.
Publication date & source: 2014, BMC Complement Altern Med. , 14:237
BACKGROUND: Red ginseng is prepared by steaming raw ginseng, a process believed
to increase the pharmacological efficacy. Further bioconversion of red ginseng
through fermentation is known to increase its intestinal absorption and
bioactivity, and bioconversion diminishes the toxicity of red ginseng's
metabolite. This study was conducted to investigate the effects of daily
supplementation with fermented red ginseng (FRG) on glycemic status in subjects
with impaired fasting glucose or type 2 diabetes.
METHODS: This study was a four-week long, randomized, double-blind,
placebo-controlled trial. Forty-two subjects with impaired fasting glucose or
type 2 diabetes were randomly allocated to two groups assigned to consume either
the placebo or fermented red ginseng (FRG) three times per day for four weeks.
Fasting and postprandial glucose profiles during meal tolerance tests were
assessed before and after the intervention.
RESULTS: FRG supplementation led to a significant reduction in postprandial
glucose levels and led to an increase in postprandial insulin levels compared to
the placebo group. There was a consistently significant improvement in the
glucose area under the curve (AUC) in the FRG group. However, fasting glucose,
insulin, and lipid profiles were not different from the placebo group.
CONCLUSION: Daily supplementation with FRG lowered postprandial glucose levels in
subjects with impaired fasting glucose or type 2 diabetes.
TRIAL REGISTRATION: ClinicalTrials.gov: NCT01826409.
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