Randomized Controlled Trial of Fosmidomycin-Clindamycin versus Sulfadoxine-Pyrimethamine in the Treatment of Plasmodium falciparum Malaria.

Author(s): Oyakhirome S, Issifou S, Pongratz P, Barondi F, Ramharter M, Kun JF, Missinou MA, Lell B, Kremsner PG

Affiliation(s): Institute for Tropical Medicine, Department for Parasitology, University of Tubingen, Wilhelmstrasse 27, 72074 Tubingen, Germany. peter.kremsner@uni-tuebingen.de.

Publication date & source: 2007-05, Antimicrob Agents Chemother., 51(5):1869-71. Epub 2007 Feb 26.

Fosmidomycin-clindamycin therapy given every 12 h for 3 days was compared with a standard single oral dose of sulfadoxine-pyrimethamine. The two treatments showed comparably good tolerabilities and had an identical high degree of efficacy of 94% in a randomized trial carried out with 105 Gabonese children aged 3 to 14 years with uncomplicated malaria. These antimalarials merit further clinical exploration.