Effect of subgingival application of topical ozonated olive oil in the treatment
of chronic periodontitis: a randomized, controlled, double blind, clinical and
microbiological study.
Author(s): Patel PV, Patel A, Kumar S, Holmes JC.
Affiliation(s): Kalindi Oro Care and Research Centre, Lanka, Uttar Pradesh, India.
punitvai@gmail.com
Publication date & source: 2012, Minerva Stomatol. , 61(9):381-98
AIM: The aim of this paper was to evaluate the efficacy of ozonated olive oil as
a monotherapy and an adjunct to scaling and root planing in the treatment of
chronic periodontitis
METHODS: A split mouth, double-blinded, randomized controlled clinical trial was
conducted on 20 subjects diagnosed with chronic periodontitis. Quadrants of each
subject were randomly assigned to four groups and treated accordingly: Group A,
scaling and root planing (SRP): Group B, topical ozonated olive oil (OZO) as an
adjunct to scaling and root planing: Group C, topical ozonated olive oil as a
monotherapy and: Group D, topical chlorhexidine gel as a monotherapy. The
quadrants were analyzed clinically by plaque index, gingival index, sulcus
bleeding index, probing pocket depth, and clinical attachment level at baseline,
2, 4, 6 and 8 weeks of time intervals. The subjects were also analyzed for
perceived pain, discomfort or tooth hypersensitivity (quadrant wise) on a Visual
Analogue Scale (VAS). Additionally, subgingival plaque samples were collected
from the two predetermined sites of each quadrant at baseline, 4 and 8 weeks for
the analysis of total bacterial counts (TBCs) and the detection of frequency of
eight putative periodontopathogens by polymerase chain reaction (PCR) method.
RESULTS: The adjunctive use of the OZO with SRP resulted in a significant
improvement (P<0.001) of clinical parameters as well as microbiological
parameters over the time and in comparison to the control groups. The OZO as
monotherapy also showed a significant improvement (P<0.001) in clinical
parameters as well as microbiological parameters over the time without any
documented side effects. However, there was a significant increase (P<0.05) in
dentinal hypersensitivity following OZO as an adjunct to scaling and root planing
therapy.
CONCLUSION: The OZO, as an adjunctive therapy as well as a mono-therapy is
efficient in improving periodontal conditions.
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