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Efficacies of quinupristin-dalfopristin combined with vancomycin in vitro and in experimental endocarditis due to methicillin-resistant Staphylococcus aureus in relation to cross-resistance to macrolides, lincosamides, and streptogramin B- type antibiotics.

Author(s): Pavie J, Lefort A, Zarrouk V, Chau F, Garry L, Leclercq R, Fantin B

Affiliation(s): Institut National de la Sante et de la Recherche Medicale (EMI 9933), Faculte de Medecine Xavier Bichat, Paris.

Publication date & source: 2002-09, Antimicrob Agents Chemother., 46(9):3061-4.

A beneficial effect of the combination of quinupristin-dalfopristin and vancomycin was observed against two methicillin-resistant strains of Staphylococcus aureus harboring or not harboring the ermC gene, which codes for constitutive macrolide, lincosamide, and streptogramin B resistance. The beneficial effect was observed in time-kill studies, in which the drugs were used at inhibitory concentrations, and in a rabbit model of endocarditis, in which the combination was highly bactericidal and more active than monotherapies.

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