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The effect of phentolamine on basal and pethidine-induced inhibition of gastric emptying in healthy volunteers.

Author(s): Petring OU

Affiliation(s): Department of Anaesthesia, Rigshospitalet, Copenhagen, Denmark.

Publication date & source: 1989-10, Br J Clin Pharmacol., 28(4):409-13.

Publication type: Clinical Trial; Randomized Controlled Trial

1. The effect of phentolamine 5 mg i.v. on basal and pethidine-induced inhibition of gastric emptying of semisolid TC-99m labelled Chelex-100 resin/oatmeal was studied in ten healthy volunteers. 2. Each volunteer acted as his/her own control. 3. Basal gastric emptying remained unchanged after administration of phentolamine. 4. Administration of phentolamine reversed the pethidine-induced inhibition of gastric emptying.

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