Comparative anti-dandruff efficacy between a tar and a non-tar shampoo.
Author(s): Pierard-Franchimont C, Pierard GE, Vroome V, Lin GC, Appa Y
Affiliation(s): Department of Dermatopathology, University of Liege, Belgium.
Publication date & source: 2000, Dermatology., 200(2):181-4.
Publication type: Clinical Trial; Randomized Controlled Trial
A randomized double-blind clinical study was conducted on two groups of 30 volunteers using either a non-tar shampoo (2% salicylic acid, 0.75% piroctone olamine and 0.5% elubiol) or a 0.5% coal tar shampoo. Subjects were diagnosed as having moderate to marked dandruff. The study consisted of a 3-week washout, followed by a 4-week treatment and a 4-week posttreatment regression phase. The clinical evaluations and subject self-assessments showed that the non-tar shampoo was as effective as the tar shampoo. Both received high approval ratings (> or =70%). Biometrological methods proved to be more sensitive than clinical evaluations to assess the efficacy of the shampoos. The non-tar shampoo yielded a significantly better reduction of Malassezia spp. counts (p<0.02) during the treatment phase and reduced the spontaneous increase in squamometry values (p< 0.01) during the posttreatment phase. It is concluded that a formulation associating salicylic acid, piroctone olamine and elubiol exhibited increased beneficial effects compared to the coal tar shampoo. Copyright 2000 S. Karger AG, Basel.
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