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Acyclovir ointment plus topical betamethasone or placebo in first episode disciform keratitis.

Author(s): Power WJ, Hillery MP, Benedict-Smith A, Collum LM

Affiliation(s): Royal Victoria Eye and Ear Hospital, Dublin, Ireland.

Publication date & source: 1992-12, Br J Ophthalmol., 76(12):711-3.

Publication type: Clinical Trial; Randomized Controlled Trial

Thirty patients with first episode disciform keratitis and with no previous steroid exposure were randomly assigned to double blind treatment with 3% acyclovir ointment and 0.1% betamethasone (Betnesol) drops or acyclovir ointment and matching placebo. In the steroid group 14 of the 15 patients healed in a mean time of 21.8 days. In the placebo group eight of the 13 patients healed in a mean time of 34.5 days. The difference in mean healing time between the two groups was significant (p < 0.05). The cumulative rate of healing was also quicker in the steroid group when compared with the placebo group (p < 0.001). Other clinical parameters improved more favourably in the combination treatment group. Four patients, two in either group, experienced a mild transient punctate epitheliopathy, but no other serious adverse effects were noted. There has been no significant difference in the recurrence rate between the two groups after a mean follow-up period of approximately 3 years.

Page last updated: 2006-01-31

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