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Herpes labialis treatment with acyclovir 5% modified aqueous cream: a double-blind randomized trial.

Author(s): Raborn GW, McGaw WT, Grace M, Percy J, Samuels S

Affiliation(s): Department of Dentistry, University of Alberta Hospitals, Edmonton, Canada.

Publication date & source: 1989-06, Oral Surg Oral Med Oral Pathol., 67(6):676-9.

Publication type: Clinical Trial; Randomized Controlled Trial

The efficacy of 5% acyclovir in a modified aqueous cream vehicle (ACV-MAC) in the treatment of recurrent herpes labialis was tested in a randomized, double-blind clinical trial with the modified aqueous cream vehicle as a control medication. The ACV-MAC formulation has previously been shown to offer superior cutaneous absorption relative to other topical acyclovir formulations. Treatment was initiated by patients within 1 hour of prodrome in an attempt to maximize clinical impact of this virustatic drug. While the patient group receiving active drug showed a trend toward accelerated healing, no significant differences for lesion or healing characteristics could be measured between the two treatment groups. It is suggested that optimal efficacy of ACV-MAC may be predicated on prophylactic treatment, that is, "trigger"-initiated rather than prodrome-initiated treatment.

Page last updated: 2006-01-31

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