"Coffee plus honey" versus "topical steroid" in the treatment of
chemotherapy-induced oral mucositis: a randomised controlled trial.
Author(s): Raeessi MA, Raeessi N(1), Panahi Y, Gharaie H, Davoudi SM, Saadat A, Karimi
Zarchi AA, Raeessi F, Ahmadi SM, Jalalian H.
Affiliation(s): Author information:
(1)Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences,
Tehran, Iran. raeessi_neda@yahoo.com.
Publication date & source: 2014, BMC Complement Altern Med. , 14:293
BACKGROUND: Oral mucositis is one of the common complications of cancer
chemotherapy and about 40% of the patients who take chemotherapy protocols,
experience this irritating problem. The purpose of this study was to draw
comparison between the therapeutic effects of our treatment modalities (topical
steroid, honey, honey plus coffee) in patients suffering from oral mucositis.
METHODS: This was a double blinded randomised clinical trial of a total of 75
eligible adult participants which they randomly fell into three treatment groups.
For all the participants a syrup-like solution was prepared. Each 600 grams of
the product consisted of "20 eight-mg Betamethasone solution ampoules" in the
Steroid (S) group, "300 grams of honey plus 20 grams of instant coffee" in the
Honey plus Coffee (HC) group, and "300 grams of honey" for the Honey (H) group.
The participants were told to sip 10 ml of the prescribed product, and then
swallow it every three hours for one week. Severity of lesions was clinically
evaluated before the treatment and also one week after the initiation of the
intervention. This study adhered to the principles of the Declaration of Helsinki
and guidelines of Good Clinical Practice.
RESULTS: This study showed that all three treatment regimens reduce the severity
of lesions. The best reduction in severity was achieved in HC group. H group and
S group took the second and third places. In other words, honey plus coffee
regimen was the most effective modality for the treatment of oral mucositis.
CONCLUSION: Oral mucositis can be successfully treated by a combination of honey
and coffee as an alternative medicine in a short time. Further investigations are
warranted in this field.
TRIAL REGISTRATION: Iranian Registry of Clinical Trials IRCT: 201104074737N3, (9
May 2011).
|
