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The effect of ipratropium nasal spray on bronchial methacholine challenge.

Author(s): Reid JK, Davis BE, Cockcroft DW

Affiliation(s): Division of Respiratory, Critical Care, and Sleep Medicine, University of Saskatchewan, 5th Floor, Ellis Hall, 103 Hospital Dr, Saskatoon, SK, Canada S7N 0W8.

Publication date & source: 2005-09, Chest., 128(3):1245-7.

Publication type: Clinical Trial; Randomized Controlled Trial

PURPOSES: To determine the effect ipratropium bromide nasal spray has on methacholine challenge testing for airway hyperresponsiveness. MATERIALS AND METHODS: Ten subjects with known airway hyperresponsiveness to methacholine who had been clinically stable in the preceding 2 months participated in a randomized, double-blind, placebo-controlled, crossover study. Methacholine challenge testing was conducted on successive days: day 1 after pretreatment with aqueous 0.03% nasal ipratropium, and day 2 with normal saline solution placebo. RESULTS: The provocative concentration of methacholine causing a 20% fall in FEV1 (PC20) was higher after nasal ipratropium than after saline solution placebo (2.1 mg/mL vs 1.6 mg/mL, p = 0.02). This difference is equal to approximately one-half concentration difference, probably within the limits of reproducibility of the test. CONCLUSIONS: Pretreatment with nasal ipratropium results in a small increase in PC20. Although this difference achieves statistical significance, it is probably not clinically significant.

Page last updated: 2006-01-31

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