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Are antibiotics necessary after 48 hours of improvement in infected/septic abortions? A randomized controlled trial followed by a cohort study.

Author(s): Savaris RF, de Moraes GS, Cristovam RA, Braun RD

Affiliation(s): Departamento e Servico de Ginecologia e Obstetricia, Universidade Federal do Rio Grande do Sul-Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil. rsavaris@hcpa.ufrgs.br

Publication date & source: 2011-04, Am J Obstet Gynecol., 204(4):301.e1-5. Epub 2010 Dec 31.

Publication type: Randomized Controlled Trial; Research Support, Non-U.S. Gov't

OBJECTIVE: We sought to investigate whether oral antibiotics are necessary, after 48 hours of clinical improvement, in uncomplicated septic abortion. STUDY DESIGN: In a randomized double-blind clinical trial, 56 women with uncomplicated septic abortion were treated with intravenous antibiotics, followed by uterine evacuation. On hospital discharge (day 1), patients were randomized to receive either oral doxycycline plus metronidazole or placebo, until completing 10 days of treatment. Clinical cure was defined by the absence of fever (<37.7 degrees C), reduced vaginal bleeding, and minimal or no pelvic pain. RESULTS: Cure was observed in all 56 patients. The institutional review board stopped the treatment arm as it was adding risk with no further benefit to the patients. An observational cohort with additional 75 cases was followed up in the no treatment arm and no failure was identified (probability of an adverse event, 0%; 95% confidence interval, 0-0.03). CONCLUSION: After 48 hours of clinical improvement, antibiotics may not be necessary. Copyright (c) 2011 Mosby, Inc. All rights reserved.

Page last updated: 2011-12-09

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