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Mydriasis induced by sub-Tenon's ropivacaine injection in patients undergoing strabismus surgery.

Author(s): Savino G, Perrotta V, Colucci D, Balia L, Sammartino M, Garra R, Petroni S, Mastrocola A, Balestrazzi E

Affiliation(s): Institute of Ophthalmology, Catholic University, Rome, Italy.

Publication date & source: 2010-04, J AAPOS., 14(2):124-6. Epub 2010 Mar 7.

Publication type: Comparative Study; Randomized Controlled Trial

PURPOSE: To investigate the effects of sub-Tenon's capsule ropivacaine injection on pupillary diameter in strabismus surgery. METHODS: A total of 16 patients were randomly assigned to 2 groups. The ropivacaine group (R) received sub-Tenon's ropivacaine 1% (2.5-3 mL) injections. In the control group (C), general anesthesia was induced and a saline solution (2.5-3 mL) was injected in the sub-Tenon's capsule. Pupillary diameter was measured at baseline and 2 and 5 minutes from the injections. The effects of the injections were expressed as a ratio of final (5 minutes) versus basal diameter. RESULTS: A significant mydriasis occurred in the ropivacaine group when compared with the control group (Group R vs Group C ratio = 2.32, p < 0.0001) or with unoperated fellow eye (R vs unoperated eye ratio = 2.29, p < 0.0001). CONCLUSIONS: Ropivacaine in the sub-Tenon's capsule induces a mydriasis probably related to a pharmacological ciliary ganglion block. Copyright 2010 American Association for Pediatric Ophthalmology and Strabismus. Published by Mosby, Inc. All rights reserved.

Page last updated: 2010-10-05

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