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Comparison of efficacy and effectiveness between ULTRACET and tramadol/acetaminophen in acute postoperative pain after upper extremity surgery.

Author(s): Sawaddiruk P, Paiboonworachat S, Janthawichai K.

Affiliation(s): Department of Anesthesiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. psawaddi@med.cmu.ac.th

Publication date & source: 2010, J Med Assoc Thai. , 93(7):812-7

OBJECTIVE: To compare the efficacy and effectiveness between ULTRACE, a new analgesic combination of tramadol/ acetaminophen, and tramadol/acetaminophen for acute postoperative pain after upper extremity surgery. STUDY DESIGN: A double blind randomized controlled trial. MATERIAL AND METHOD: One hundred and eighty patients who underwent upper extremity surgery under brachial plexus block were randomized to receive either ULTRACE (n = 87) or tramadol and acetaminophen (n = 93) immediately after surgery in the postanesthetic care unit (PACU). Total morphine requirement, pain score (VRS) and drug adverse effects were compared between those two groups using independent single t-test, Mann-Whitney U-test, Chi-square test and Fisher-exact test respectively. RESULTS: Total morphine requirement was significantly lower in subjects who used ULTRACE when compared with the tramadol and acetaminophen group (0.51 and 0.69 mg in the first 6 hours after the operation, 0.0 and 0.13 mg in hours 6-12 after the operation). Moreover there were fewer side effects in this ULTRACE group too. CONCLUSION: ULTRACET has more efficacy and fewer side effects when compared with tramadol and acetaminophen in acute postoperative pain surgery.

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