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[Thrombosis prevention with heparin/dihydroergotamine versus heparin/Sintrom in Ender nailing of pertrochanteric fractures]

Author(s): Schlag G, Gaudernak T, Pelinka H, Redl H, Kuderna H, Poigenfurst J

Affiliation(s): Ludwig-Boltzmann-Institut fur Experimentelle Traumatologie, Wien.

Publication date & source: 1988-02, Unfallchirurgie., 14(1):12-21.

Publication type: Clinical Trial; Comparative Study; English Abstract; Randomized Controlled Trial; Review

The effect of either (randomized) Heparin/Dihydroergotamine (HDHE) or heparin-acenocoumarin (Hep/S) on the incidence of deep-vein thrombosis in the legs was studied in 212 women of more than 60 years of age with hip fractures. All patients were screened with the 125-I-fibrinogen uptake test (FUT) confirmed by a bilateral ascending venogram upon positive FUT. This revealed good sensitivity and specificity (85/84%) for the FUT. Deep vein thrombosis developed in 37.6% of the HDHE group and in 59.1% of the Hep/S group which was significantly different (p less than 0.005). The calculated thrombosis risk was significantly diminished (by 38% - p less than 0.005) in the HDHE group. Therefore we conclude that in traumatology Heparin/Dihydroergotamine seems to be the prophylaxis of choice.

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