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[Is subconjunctival steroid administration in addition to local therapy after cataract operations necessary? A laser tyndallometric study]

Author(s): Schmitt K, Hessemer V

Affiliation(s): Universitats-Augenklinik Giessen.

Publication date & source: 1995-06, Ophthalmologe., 92(3):303-6.

Publication type: Clinical Trial; Comparative Study ; English Abstract; Randomized Controlled Trial

Subconjunctival steroids are often injected at the end of cataract surgery. In the present laser flare-cell meter study, we investigated whether this procedure improves the anti-inflammatory effect of steroid eye drops. PATIENTS AND METHODS: Thirty patients (69-81 years of age) without preexisting deficiencies of the blood-aqueous barrier were investigated preoperatively and after ECCE with PC-IOL implantation. The laser flare-cell meter (model FC 1000; Kowa Company) used for examination permits sensitive and exact determination of aqueous flare. The patients were randomly assigned to one of the following two treatment groups: group A: topical therapy with prednisolone 1% eye drops (Inflanefran forte) 5 times per day; group B: subconjunctival injection of 4 mg dexamethasone (Fortecortin) immediately at the end of surgery; topical therapy as in group A. In addition, all patients received antibiotic therapy using gentamicin eye drops. Oral steroids were not administered. RESULTS: Under topical therapy with prednisolone 1% (group A), the aqueous flare (in photon counts/millisecond) increased from a preoperative value of 10.2 +/- 2.5 (mean +/- SD) to 37.3 +/- 11.1 in the afternoon after surgery (8 h postoperatively) and decreased to 30.9 +/- 38.7 and 27.8 +/- 3.2 on days 1 and 3 after surgery. With additional steroid injection (group B), the flare accounted to 31.7 +/- 8.7 in the afternoon after surgery and to 31.3 +/- 5.9 and 27.1 +/- 4.7 on days 1 and 3 after surgery, respectively. There was no significant group difference (P > 0.3). CONCLUSIONS: After uncomplicated cataract surgery, subconjunctival steroid injection (4 mg dexamethasone) does not improve the effect of potent anti-inflammatory topical therapy (prednisolone 1% eye drops).

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