A comparison of second and third generations combined oral contraceptive pills'
effect on mood.
Author(s): Shahnazi M(1), Farshbaf Khalili A(1), Ranjbar Kochaksaraei F(2), Asghari
Jafarabadi M(3), Gaza Banoi K(1), Nahaee J(1), Bayati Payan S(1).
Affiliation(s): Author information:
(1)Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of
Medical Sciences, Tabriz, IR Iran.
(2)Department of Psychiatry, Tabriz University of Medical Sciences, Tabriz, IR Iran.
(3)Department of Biochemistry, Nutrition Therapy, Community Nutrition, School of
Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, IR Iran.
Publication date & source: 2014, Iran Red Crescent Med J. , 16(8):e13628
BACKGROUND: Most women taking combined oral contraceptives (COCs) are satisfied
with their contraceptive method. However, one of the most common reasons reported
for discontinuation of combined oral contraceptives (COCs) is mood deterioration.
OBJECTIVES: This study aimed to compare effects of the second and third
generation oral contraceptive pills on the mood of reproductive women.
MATERIALS AND METHODS: This randomized, double-blind, controlled clinical trial
was conducted in reproductive women at health centers in Tehran, Iran.
Participants were randomized into the second and third generation oral
contraceptive groups. Positive and negative moods were recorded using positive
affect, negative affect scale (PANAS) tools at the end the second and fourth
months of the study. Data analysis was carried out using ANOVA and P Values <
0.05 was considered significant.
RESULTS: Statistically significant difference was seen in positive and negative
mood changes in women receiving contraceptive pills. The second generation oral
contraceptive pills resulted in a decrease in positive mood (95% CI: 43.39 to
38.32 in second month and 43.39 to 26.05 in four month) and increase in negative
mood (95% CI: 14.23 to 22.04 in second month and 14.23 to 32.26 in four month - P
< 0.001), but the third generation led to an increase in positive mood (95% CI:
22.42 to 25.60 in second month and 22.42 to 33.87 in four month) and decrease in
negative mood (95% CI: 36.78 to 31.97 in second month and 36.78 to 22.65 in four
month - P < 0.001).
CONCLUSIONS: Third generation combined oral contraceptive pills have a better
effect on mood in women in reproductive ages than the second generation pills. It
can be recommended as a proper combined oral contraceptive in Iran.
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