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Prophylactic antibiotics in open mesh repair of inguinal hernia - a randomized controlled trial.

Author(s): Shankar VG, Srinivasan K, Sistla SC, Jagdish S

Affiliation(s): Department of Surgery, JIPMER (Jawaharlal Institute of Postgraduate Medical Education and Research), Puducherry 605006, India. drgomathishankar@gmail.com

Publication date & source: 2010, Int J Surg., 8(6):444-7. Epub 2010 Jun 9.

Publication type: Research Support, Non-U.S. Gov't

The role of prophylactic antibiotics in mesh repair of inguinal hernia is unclear. A Cochrane meta-analysis in 2005 concluded that "antibiotic prophylaxis for elective inguinal hernia repair cannot be firmly recommended or discarded" and "further studies are needed, particularly on the use for mesh repair." So, we designed a study to define the role of prophylactic antibiotics in mesh repair of inguinal hernia. We conducted a prospective, randomized, double-blind, trial comparing wound infection rates in 450 patients (225 received intravenous Cefazolin, 225 received a placebo) undergoing primary inguinal hernia repair electively using polypropylene mesh. 334 patients who completed a followup period of one month were analyzed. Age, American Society of Anesthesiologists class, type of hernia, type of anesthesia, grade of surgeon, pre and postoperative hospital stay and duration of operation were recorded. CDC criteria was used to define wound infection. Groups were well matched for all preoperative variables studied. The overall infection rate was 8.7% (29 out of 334). The incidence of wound infection in antibiotic group was 7% and 10.5% in control group. One from each group developed deep surgical site infection. Most of the infections occurred between the 7th and 12th post-operative day after discharge from the hospital. Antibiotic prophylaxis was associated with decreased incidence of wound infection when compared to control group, but the difference was not statistically significant. Based on our results we do not recommend the routine use of antibiotic prophylaxis in elective mesh repair of inguinal hernias. Copyright (c) 2010 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

Page last updated: 2010-10-05

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