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Evaluation of the anti-endotoxin effects of polymyxin B in a feline model of endotoxemia.

Author(s): Sharp CR, DeClue AE, Haak CE, Honaker AR, Reinero CR

Affiliation(s): Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, 900 E Campus Drive, Columbia, MO 65211, USA.

Publication date & source: 2010-04, J Feline Med Surg., 12(4):278-85. Epub 2010 Feb 13.

Publication type: Research Support, Non-U.S. Gov't

Directed, effective therapies for feline sepsis are needed to reduce the high morbidity and mortality associated with this disease. We investigated the anti-endotoxin effects of polymyxin B (PMB) in a blinded, placebo controlled fashion, both ex vivo in a feline whole blood culture system and in vivo, using a low-dose endotoxin infusion in cats. Serial measures of systemic inflammation, and hemodynamic stability, were compared between groups. Ex vivo, PMB significantly decreased lipopolysaccharide-induced tumor necrosis factor (TNF) production from whole blood. PMB (1mg/kg over 30min) demonstrated anti-endotoxin effects in vivo, including decreased peak plasma TNF activity (P<0.001) and increased white blood cell count (P=0.019), with no adverse effects. Given the apparent safety and anti-endotoxin effects of PMB in this endotoxemia model, a carefully designed, randomized, blinded, placebo controlled clinical trial evaluating the use of PMB in naturally occurring Gram-negative feline sepsis should be considered. Copyright 2010 ISFM and AAFP. Published by Elsevier Ltd. All rights reserved.

Page last updated: 2010-10-05

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