Dimenhydrinate pretreatment in patients receiving intra-arterial ioxaglate:
effect on nausea and vomiting.
Author(s): Smith DC, Taylor FC, McKinney JM.
Affiliation(s): Department of Radiology, Loma Linda University Medical Center, Calif 92354, USA.
Publication date & source: 1995, Can Assoc Radiol J. , 46(6):449-53
OBJECTIVE: To determine the effectiveness of the antihistamine dimenhydrinate
(Dramamine) as a prophylactic agent against the nausea and vomiting that
occasionally accompany the use of ioxaglate.
PATIENTS AND METHODS: Three hundred patients (165 men and 135 women, ranging in
age from 18 to 89 [mean 62] years) undergoing noncoronary arteriography received
dimenhydrinate or placebo before the injection of the low-osmolality contrast
material ioxaglate (Hexabrix). The patients were observed and questioned about
nausea and vomiting, as well as many other possible reactions to the contrast
material.
RESULTS: There were no statistical differences in the occurrence of adverse
reactions between the groups receiving dimenhydrinate and placebo (chi 2 or
Fisher's exact test, p > 0.05).
CONCLUSION: Dimenhydrinate, as administered in this study, was ineffective as a
prophylactic agent against adverse reactions accompanying administration of
ioxaglate.
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