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Prostaglandin E1 : electrophysiological safety in patients with congestive heart failure and peripheral arterial occlusive disease. The Alprostadil Investigators.

Author(s): Somberg JC, Yelamanchi V, Molnar J, Aschermann M, Bernink PJ, Caspi A, Marmor A, Rabinowitz B, Reisin L, Ruzyllo W

Affiliation(s): Department of Medicine, Finch University of Health Sciences/The Chicago Medical School, North Chicago, IL 60064, USA.

Publication date & source: 1997-11, Am J Ther., 4(11-12):401-4.

Publication type: Clinical Trial; Multicenter Study; Randomized Controlled Trial

Prostaglandin E ( 1 ) (PGE ( 1 ) ), the active ingredient of the drug alprostadil-alpha-cyclodextrin, has been effective in mitigating the clinical manifestations of peripheral arterial occlusive disease (PAOD). PGE ( 1 ) often is administered to patients with the potential for developing serious arrhythmias, presenting potential safety hazards if the drug caused or potentiated arrhythmias. However, PGE ( 1 ) has antiadrenergic properties and, theoretically, might have an antiarrhythmic action. Therefore, the effect of PGE ( 1 ) on frequency and severity of atrial and ventricular arrhythmias was evaluated from 48-hour electrocardiographic recordings in patients receiving PGE ( 1 ) therapy for severe PAOD. No significant effects on arrhythmia frequency or severity, and no evidence of proarrhythmia, was apparent after PGE ( 1 ) administration.

Page last updated: 2006-01-31

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