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Recurrent herpetic keratitis during topical acyclovir application.

Author(s): Soriano JM, Funk J, Janknecht P, Matz B

Affiliation(s): Universitats-Augenklinik Freiburg, Germany.

Publication date & source: 1992-07, Eur J Ophthalmol., 2(3):155-7.

Publication type: Case Reports

Dendritic herpetic keratitis developed in a 49-year-old patient during topical acyclovir treatment. A positive herpes simplex culture was obtained. After acyclovir was replaced by trifluorothymidine and interferon, the dendritic lesion disappeared and herpes simplex culture became negative. Six months later a carcinoma of the larynx was diagnosed. The acyclovir-resistant herpetic keratitis may be associated with the carcinoma because resistant herpes simplex virus strains are predominantly described in patients suffering from immune deficiency.

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