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Guided tissue regeneration combined with a deproteinized bovine bone mineral (Bio-Oss) in the treatment of intrabony periodontal defects: 6-year results from a randomized-controlled clinical trial.

Author(s): Stavropoulos A, Karring T

Affiliation(s): Department of Periodontology and Oral Gerontology, School of Dentistry, University of Aarhus, Aarhus, Denmark. stavropoulos@odont.au.dk

Publication date & source: 2010-02, J Clin Periodontol., 37(2):200-10.

AIM: To present the 6-year results of a randomized-controlled clinical trial evaluating guided tissue regeneration (GTR) combined with or without deproteinized bovine bone mineral (DBBM) in intrabony defects. MATERIAL & METHODS: In each of 45 patients, one defect was treated with GTR combined with DBBM hydrated in saline (DBBM-) or gentamicin sulphate (DBBM+) or with GTR alone. Clinical parameters were recorded pre-surgery, at 1 and 6 years postsurgery. RESULTS: Thirty-six patients/33 teeth were available for the 6-year control. Statistically significant clinical improvements were observed for all treatments. Clinical attachment level (CAL) gain averaged 2.5 mm (DBBM-), 4.1 mm (DBBM+), and 3.0 mm (GTR) at 1 year postsurgery, and remained stable over 5 additional years (2.3, 4.1, and 2.7 mm, respectively). Treatment did not appear to influence residual probing depths (PDs) or CAL gains at 6 years postsurgery, or the extent of PD and CAL change from 1 to 6 years, and did not associate with sites losing CAL during follow-up. No association of grafting with sites showing CAL gain >or=4 mm at the 1- or 6-year control was observed. CONCLUSION: The improvements in periodontal conditions obtained after GTR treatment with or without the adjunct use of DBBM can be preserved on a long-term basis.

Page last updated: 2010-10-05

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