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A new once-daily formulation of tolterodine provides superior efficacy and is well tolerated in women with overactive bladder.

Author(s): Swift S(1), Garely A, Dimpfl T, Payne C; Tolterodine Study Group.

Affiliation(s): Author information: (1)Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC 29425, USA. swifts@musc.edu

Publication date & source: 2003, Int Urogynecol J Pelvic Floor Dysfunct. , 14(1):50-4; discussion 54-5

This study evaluated the efficacy and tolerability of new extended-release (ER) tolterodine for the treatment of overactive bladder in women. In this subpopulation analysis of a double-blind multicenter trial, 1235 female patients were randomized to oral therapy with tolterodine ER 4 mg once daily (n=417), tolterodine IR 2 mg twice daily (n=408) or placebo (n=410) for 12 weeks. Both formulations reduced the mean number of urge incontinence episodes per week (both P=0.001 vs placebo); tolterodine ER was more effective than tolterodine IR (P=0.036). Both formulations significantly improved all other micturition chart variables compared to placebo. Dry mouth was the most common adverse event. There were no safety concerns. Toltrodine ER 4 mg once daily is effective and well tolerated in the treatment of women with overactive bladder, and reduces urge incontinence episodes more than the existing IR twice-daily formulation.

Page last updated: 2015-08-10

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