Loracarbef (LY 163892) vs amoxicillin/clavulanate in bacterial maxillary sinusitis.
Author(s): Sydnor TA Jr, Scheld WM, Gwaltney J Jr, Nielsen RW, Huck W, Therasse DG
Affiliation(s): Lilly Research Laboratories, Indianapolis, IN.
Publication date & source: 1992-05, Ear Nose Throat J., 71(5):225-32.
Publication type: Clinical Trial; Randomized Controlled Trial
Loracarbef (LY 163892), a beta-lactam antibiotic (carbacephem), was compared with amoxicillin/clavulanate potassium in a 10-day, single-blind, randomized parallel trial in the treatment of acute bacterial maxillary sinusitis. Based on posttherapy aspirate and culture, there was a 95.2% bacteriologic cure rate in patients receiving loracarbef (400 mg twice daily) and an 86.7% cure rate in patients receiving amoxicillin/clavulanate (500/125 mg three times daily) (p = 0.359). Loracarbef was comparable in efficacy to amoxicillin/clavulanate with a more desirable safety profile.
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