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Endocarditis due to vancomycin-resistant Enterococcus faecium in an immunocompromised patient: cure by administering combination therapy with quinupristin/dalfopristin and high-dose ampicillin.

Author(s): Thompson RL, Lavin B, Talbot GH

Affiliation(s): Infectious Disease Section, Group Health Cooperative of Puget Sound, Seattle, WA 98112, USA. thompson.rl@ghc.org

Publication date & source: 2003-08, South Med J., 96(8):818-20.

Publication type: Case Reports

A 56-year-old man with diabetes mellitus and cadaveric renal transplantation had vancomycin-resistant Enterococcus faecium tricuspid valve endocarditis. Relapse followed 6 weeks of treatment with intravenous gentamicin and high-dose ampicillin. On the basis of previous data suggesting the potential for synergistic activity of quinupristin/dalfopristin plus high-dose ampicillin, therapy with this combination was administered for 63 days. Cure was achieved and later confirmed at 2-year follow-up.

Page last updated: 2006-01-31

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