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Comparison of the effectiveness of single versus double intrauterine insemination with three different timing regimens.

Author(s): Tonguc E, Var T, Onalan G, Altinbas S, Tokmak A, Karakas N, Gulerman C

Affiliation(s): Zekai Tahir Burak Women's Health Research and Education Hospital, Department of Reproductive Endocrinology, and Baskent University School of Medicine, Department of Obstetrics and Gynecology, Ankara, Turkey. esratonguc@yahoo.com

Publication date & source: 2010-09, Fertil Steril., 94(4):1267-70. Epub 2009 Sep 26.

Publication type: Comparative Study; Randomized Controlled Trial

OBJECTIVE: To compare double insemination with two different single insemination regimens. DESIGN: Prospective study. SETTING: Tertiary education and research hospital. PATIENT(S): Four hundred and fifty patients with unexplained infertility, male factor, and ovulatory dysfunction underwent controlled ovarian hyperstimulation with gonadotropin. INTERVENTION(S): The patients were divided randomly into three groups: patients in group 1 underwent a single preovulatory intrauterine insemination (IUI) performed 24 hours after hCG administration. Patients in group 2 underwent two IUIs performed 12 and 36 hours after hCG administration. Patients in group 3 underwent a single periovulatory IUI performed 36 hours after hCG administration. MAIN OUTCOME MEASURE(S): Pregnancy rate. RESULT(S): The total pregnancy rate per patient was 14.2 % (64 pregnancies in 450 patients). Group 1 had 17 pregnancies (11.3%), while groups 2 and 3 had 21 (14.0%) and 26 (17.2%) pregnancies, respectively. The difference between the three groups in regard to pregnancy rates was statistically not significant. CONCLUSION(S): Despite the 36th hour being the preferred timing for IUI, there was no difference regarding pregnancy rates between single 24th hour and double 12th- and 36th-hour inseminations. This finding suggests that the 24th-hour IUI might be preferred in demanding situations. Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Page last updated: 2010-10-05

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