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Comparison of aliskiren/hydrochlorothiazide combination therapy and amlodipine monotherapy in patients with stage 2 systolic hypertension and type 2 diabetes mellitus.

Author(s): Townsend RR, Forker AD, Bhosekar V, Yadao A, Keefe DL

Affiliation(s): From the University of Pennsylvania Medical Center, Philadelphia, PA ; 1 St Luke's Lipid and Diabetes Research Center, Kansas City, MO ; 2 Novartis Healthcare Pvt Ltd, Madhapur, Hyderabad, India ; 3 and Novartis Pharmaceuticals Corporation, East Hanover, NJ4.

Publication date & source: 2011-12, J Clin Hypertens (Greenwich)., 13(12):889-97. Epub 2011 Nov 11.

J Clin Hypertens (Greenwich). 2011;13:889-897. (c)2011 Wiley Periodicals, Inc. Patients with stage 2 hypertension and diabetes are at high cardiovascular risk and require large blood pressure (BP) reductions to reach treatment goals. This randomized double-blind study compared aliskiren/hydrochlorothiazide (HCTZ) combination therapy with amlodipine monotherapy in 860 patients with mean sitting systolic BP (msSBP) >/=160 mm Hg to <200 mm Hg and type 2 diabetes. Patients received either once-daily aliskiren/HCTZ 150/12.5 mg or amlodipine 5 mg for 1 week then force-titrated to double the doses for 7 weeks. Baseline BP was 167.7/91.4 mm Hg. At week 8 end point, aliskiren/HCTZ provided significantly greater reductions in msSBP than amlodipine (28.8 mm Hg vs 26.2 mm Hg; P<.05). Mean sitting diastolic BP reductions were similar with aliskiren/HCTZ (9.9 mm Hg) and amlodipine (9.0 mm Hg). Achievement of BP control (<130/80 mm Hg) was significantly greater with aliskiren/HCTZ (23.2%) than amlodipine (13.8%; P<.0001). Aliskiren/HCTZ provides substantial msSBP reductions and greater BP control rates than amlodipine, and offers an attractive treatment option for patients with hypertension and diabetes mellitus. J Clin Hypertens (Greenwich). 2011;00:00-00. (c)2011 Wiley Periodicals, Inc. (c) 2011 Wiley Periodicals, Inc.

Page last updated: 2011-12-09

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