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Bisphosphonate-induced osteonecrosis of the jaws: a case report and literature review.

Author(s): Tsai WS, Haghighi K, Placa SJ

Affiliation(s): Department of Dentistry, Jersey Shore University Medical Center, Neptune, USA.

Publication date & source: 2006-05, Gen Dent., 54(3):215-9

Publication type: Case Reports; Review

Bisphosphonates are nonmetabolized analogues of pyrophosphate that are used for treating skeletal complications secondary to bone metastases. These drugs are capable of localizing to bone and inhibiting osteoclastic activity; however, their exact mechanisms of action remain unclear. Recently, it has been documented that administration of bisphosphonates has been associated with osteonecrosis of the jaws. This article details the case of a woman who received intravenous administration of bisphosphonate for metastatic breast cancer and subsequently developed osteonecrosis in both the maxillary and mandibular jaws.

Page last updated: 2006-11-05

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