The safety of anidulafungin.
Author(s): Vazquez JA
Affiliation(s): Senior Staff, Henry Ford Hospital, Division of Infectious Diseases, 2799 West Grand Boulevard, CFP-202, Detroit, MI 48202, USA. jvazque1@hfhs.org
Publication date & source: 2006-11, Expert Opin Drug Saf., 5(6):751-8.
Publication type: Review
The echinocandins are a new class of antifungal that have shown promising results in treating a variety of fungal infections. Anidulafungin is the newest approved echinocandin and may have some advantages over existing antifungals. It has activity against a broad range of fungi. It is unique because it undergoes a process of slow chemical degradation rather than being metabolised. Studies evaluating the use of anidulafungin in combination with other commonly used drugs have not demonstrated any significant drug-drug interactions or adverse events. Thus far, anidulafungin appears to have an excellent safety profile with few adverse events. Based on early clinical experience, it appears that anidulafungin will be a valuable and safe asset in the management of serious and difficult-to-treat fungal infections.
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