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Probiotics and intestinal colonization by vancomycin-resistant enterococci in mice and humans.

Author(s): Vidal M, Forestier C, Charbonnel N, Henard S, Rabaud C, Lesens O

Affiliation(s): Service des maladies infectieuses et tropicales, CHU Clermont-Ferrand, Clermont-Ferrand, France.

Publication date & source: 2010-07, J Clin Microbiol., 48(7):2595-8. Epub 2010 Apr 26.

Publication type: Randomized Controlled Trial

We investigated the impact of probiotics on the intestinal carriage of vancomycin-resistant enterococci (VRE). Administration of Lactobacillus rhamnosus Lcr35 but not Escherichia coli Nissle reduced, although not significantly, the density of VRE colonization in a murine model. No effect of Lcr35 was observed in a double-blind placebo randomized study, involving nine patients.

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