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Drug monitoring of lamotrigine and oxcarbazepine combination during pregnancy.

Author(s): Wegner I, Edelbroek P, de Haan GJ, Lindhout D, Sander JW

Affiliation(s): SEIN, Epilepsy Institute in the Netherlands, Zwolle, The Netherlands. iwegner@sein.nl

Publication date & source: 2010-12, Epilepsia., 51(12):2500-2. Epub 2010 Nov 3.

Publication type: Case Reports; Research Support, Non-U.S. Gov't

Little is known about pregnancy-induced alterations in the pharmacokinetics of the newer antiepileptic drugs, especially when used in combinations. Two women receiving combination therapy of lamotrigine (LTG) and oxcarbazepine (OXC) were followed prospectively during pregnancy and puerperium. Steady-state concentrations of LTG and the active metabolite of OXC, 10-hydroxycarbazepine (MHD), were measured at regular intervals using a dried blood spot method, and clearances were calculated. A strong effect of pregnancy on the clearance of both LTG and MHD was seen. An increase in seizure frequency occurred in both women. This stresses the importance of therapeutic drug monitoring of LTG and MHD during pregnancy. In case of breakthrough seizures or increased seizure frequency, dosage adjustment of both drugs may be required. Wiley Periodicals, Inc. (c) 2010 International League Against Epilepsy.

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