DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Stability and compatibility of doxofylline with phentolamine mesilate in 0.9% sodium chloride or 5% dextrose injection for intravenous infusion.

Author(s): Xu F, Xu G, Su L, Feng E

Affiliation(s): Kunming General Hospital of Chengdu Military Region, Kunming, Yunnan, China. xu_fan@126.com

Publication date & source: 2011-02, J Clin Pharm Ther., 36(1):99-102. Epub 2010 Oct 19.

WHAT IS KNOWN AND OBJECTIVE: The use of extemporaneously prepared admixtures of drugs must be supported by documentation of their chemical stability. The objective was to assess the physical compatibility and the chemical stability of doxofylline with phentolamine mesilate in 0.9% sodium chloride or 5% dextrose injection for intravenous infusion. METHODS: Total volumes of 20 and 1 mL of doxofylline solution and phentolamine mesilate solution, respectively, were added to 250 mL polyolefin bags containing 5% dextrose injection or 0.9% sodium chloride injection. Bags were stored for 24 h at 20-25 degrees C. Chemical compatibility was measures with high-performance liquid chromatography, and physical compatibility was determined visually. RESULTS: The samples were clear and colourless when viewed in normal fluorescent room light. The pH value and particulate content of the admixtures exhibited little change. The retentions of the initial concentration of doxofylline and phentolamine mesilate in the admixtures were within 97-105%. Doxofylline and phentolamine mesilate were stable in 5% dextrose injection or in 0.9% sodium chloride for up to 24 h at 20-25 degrees C. WHAT IS NEW AND CONCLUSION: Doxofylline and phentolamine mesilate mixed in both 5% dextrose injection and 0.9% sodium chloride injection in 250 mL multilayer polyolefin bags at concentrations of 0.74 mg/mL and 36.9 mug/mL, respectively, were stable for up to 24 h at 20-25 degrees C. (c) 2010 The Authors. JCPT (c) 2010 Blackwell Publishing Ltd.

Page last updated: 2011-12-09

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017