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[Assessment of curative effect on erectile dysfunction of two drugs]

Author(s): Yang DZ, Ma XN, Yu ZJ, Jiao Y

Affiliation(s): Department of Sexual Medicine, No 402 Hospital, Ministry of Electronic Industry, Beijing 100039, China.

Publication date & source: 2003, Zhonghua Nan Ke Xue., 9(4):260-2.

OBJECTIVES: To further discuss the method of evaluating curative effect on erectile dysfunction(ED). METHODS: Clinical trials(Phase II) of sildenafil and phentolamine were both 8-week-long, randomized, double-blind and placebo-controlled. Not only the curative effect between each treatment group and placebo group but also between the treatment groups were compared. The dosage of sildenafil and phentolamine was respectively 50-100 mg and 40 mg. RESULTS: Efficiency, success rate of sexual intercourse and general curative effect in sildenafil and phentolamine groups were respectively 79.17%, 75.00%, 83.33% and 52.38%, 85.71%, 52.38%. The result revealed a statistically significant (P < 0.05) improvement over placebo. But no obvious differences were shown between the two treatment groups(P > 0.05). CONCLUSIONS: Most assessments of curative effect of ED drugs come from questionnaires answered subjectively by patients. The Lack of objective assessment criteria way lead to the non-conformity between trial results and clinical practices. So the curative effect of drugs shall be assessed more accurately and from more perspectives.

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